Figure 1: Reactivities of modified cytosines in sequencing approaches. Recognizing the constraints of chemical deamination, we were drawn toward a natural analog of this reaction: enzymatic ...

The spontaneous deamination of cytosine is a major source of transitions from C•G to T•A base pairs, which account for half of known pathogenic point mutations in humans. The ability to efficiently ...

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is subjected to the host’s deamination system that includes the cytidine-to-uridine (C-to-U) deamination by apolipoprotein B messenger ...