A study conducted by the Development and Growth Control Laboratory at IRB Barcelona sheds light on the contribution of DNA damage to the invasiveness of cancer cells. The discovery challenges the ...

Chromosomal instability is a feature of solid tumors such as carcinoma. Likewise, cellular senescence is a process that is highly related to cellular ageing and its link to cancer is becoming ...

Chromosomal instability is a feature of solid tumours such as carcinoma. Likewise, cellular senescence is a process that is highly related to cellular ageing and its link to cancer is becoming ...

A new tool, ContactTracing, enabled researchers to show that chronic activation of the STING pathway, induced by chromosomal instability (CIN), promotes downstream changes in cellular signaling. This ...

The paper S.F. Bakhoum et al., “Chromosomal instability drives metastasis through a cytosolic DNA response,” Nature, 553:467-72, 2018. Aneuploidy—the presence of abnormal numbers of chromosomes in a ...

New research finds an unexpected link between chromosomal instability and epigenetic alternations, both of which are hallmarks of cancer -- especially advanced, drug-resistant cancers. A graduate ...

Scientists have found a way to identify and interpret 'signatures' that reveal the complex genetic causes of some of the deadliest cancers – which often have a survival rate of less than 10%. The ...

Chromosomal aberrations, encompassing both structural and numerical chromosome abnormalities, are fundamental indicators of genomic instability with far‐reaching implications for cancer risk. These ...

Utilizing commercial health insurance claims data to identify the impact of cancer screening and estimate the added benefit of a multicancer liquid biopsy ordered during routine physical exams.

Paclitaxel is one of the most effective chemotherapy drugs for breast cancer. It is used for breast cancer in the early stages as well as for metastatic breast cancer, in combination with other ...

Researchers have revealed the mechanisms by which cells enter senescence because of an imbalance in the number of chromosomes. Chromosomal instability is a common trait in most solid tumors, such as ...