It has long been recognized that the thermodynamics of mRNA–tRNA base pairing is insufficient to explain the high fidelity and efficiency of aminoacyl-tRNA (aa-tRNA) selection by the ribosome. To ...
During the elongation cycle of protein biosynthesis on the ribosome, elongation factor G (EF-G), a GTPase, facilitates the translocation of the A- and P-site tRNAs to the P and E sites, respectively, ...
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