Disc Medicine is planning to launch a trial by year's end to test DISC-3405, its treatment candidate for iron overload, in ...

Patients with serum ferritin levels higher than 1000 μg/L show a 91% increased risk for any fracture, with a doubled risk for vertebral and humerus fractures compared with those without iron overload.

Merganser Biotech, a drug licensing and development startup, has secured funding from a consortium that includes BioAdvance, the Biotechnology Greenhouse of Southeastern Pennsylvania and individual ...

BMP, bone morphogenetic protein; BMPR, bone morphogenetic protein receptor; HAMP, hepcidin; HFE, hereditary hemochromatosis protein; HJV, hemojuvelin; Holo-Tf, holo ...

Expert Rev Mol Diagn. 2010;10(6):755-763. The diagnosis is based on a three-step strategy. The first step is recognizing clinical signs and symptoms. Many symptoms in various combinations may suggest ...

For people who need blood transfusions, iron can accumulate in the heart and liver, causing damage and sometimes death. Doctors often prescribe medications called chelators that bind to iron and ...

The clinical introduction of hepcidin25 (Hep25) has led to a more detailed understanding of its relationship with ferroportin (FP) and divalent metal transporter1 in primary iron overload syndromes ...

Saturation of TfR1 leads to the dissociation of Hfe and the binding of the alter to the TfR2, which in turn influences the binding of BMP6 to its receptors on the membrane. Increased liver iron ...

Rhino horns may be the key to saving the endangered species from a potentially fatal condition: iron overload disorder. With the species dwindling in number, if zookeepers were alerted to the ...

Dublin, Oct. 01, 2025 (GLOBE NEWSWIRE) -- The "Iron Overload Syndrome Market - A Global and Regional Analysis: Focus on Country and Region - Analysis and Forecast, 2025-2035" report has been added to ...

Sometimes, people with mild thalassemia may be told to supplement with iron. Iron supplements are only appropriate for certain types of thalassemia, though, and can be dangerous for people with more ...