Proline-directed phosphorylation is a posttranslational modification that is instrumental in regulating signaling from the plasma membrane to the nucleus, and its dysregulation contributes to cancer ...

PIN1 is a member of the evolutionarily conserved peptidyl-prolyl isomerase family of proteins, which encompasses the cyclophilins, FK506-binding proteins and the parvulins. PIN1 binds to and alters ...