A new study led by researchers at the University of Pittsburgh (Pitt) and UPMC Hillman Cancer Center has shown that an enzyme called PARP1 is involved in the repair of telomeres, the lengths of DNA ...

This new resource aims to change that by providing a detailed framework for understanding how different cancers maintain ...

Imagine your DNA as a set of shoelaces. Telomeres are like the plastic tips at the ends of those shoelaces, preventing them from fraying and unraveling. Structurally, telomeres are repetitive ...

A new study led by University of Pittsburgh and UPMC Hillman Cancer Center researchers shows that an enzyme called PARP1 is involved in repair of telomeres, the lengths of DNA that protect the tips of ...

Half a century ago, scientists Jim Watson and Alexey Olovnikov independently realized that there was a problem with how our DNA gets copied. A quirk of linear DNA replication dictated that telomeres ...

A new study suggests vitamin D supplements might slow cellular aging by protecting telomeres. Vitamin D supplements might slow cellular aging by preventing the loss of telomeres, DNA sequences at the ...

A defining characteristic of cancer cells is their immortality. Usually, normal cells are limited in the number of times they can divide before they stop growing. Cancer cells, however, can overcome ...

A defining characteristic of cancer cells is their immortality. Usually, normal cells are limited in the number of times they can divide before they stop growing. Cancer cells, however, can overcome ...

In absence of TARG1, ADP-ribose accumulated at telomeres, leading to disruption of telomere replication and premature telomere shortening. To show that these telomere defects were due to modification ...

Vitamin D supplements might slow cellular aging by preventing the loss of telomeres, DNA sequences at the ends of chromosomes that shorten in old age, a new study suggests. The health effects of these ...