Regulatory mechanisms governing stem cell quiescence in glandular organs remain ill-defined. Here, multi-omics profiling ...

Scientists have known for decades that opioids relieve pain by binding to molecular switches in the brain called mu-opioid ...

This study presents a valuable finding about how receptor-ligand binding pathways with multi-site phosphorylation can show non-monotonic responses to increasing ligand affinity and to kinase activity.

Farkas has received research grants from CSL Behring and Pharvaris; speaker fees from CSL Behring and Shire/Takeda; travel grants from CSL Behring, Shire/Takeda, Pharming, Kalvista, Pharvaris, ...

In a discovery that could guide the development of next-generation antidepressants and antipsychotic medications, researchers at the Icahn School of Medicine at Mount Sinai have developed new insights ...

Cutaneous squamous-cell carcinoma (SCC) is primarily caused by oncogenesis mediated by ultraviolet radiation, and β-human papillomavirus (β-HPV) is believed to be a mere facilitator that is ...

Jacob E. Berchuck, MD, highlights novel findings pointing to androgen receptor signaling and Wnt pathway activation as key correlates of poor response to therapy. Emerging research is shedding light ...

Results From First-in-Human Phase I Study of a Novel CD19-1XX Chimeric Antigen Receptor With Calibrated Signaling in Large B-Cell Lymphoma The following represents disclosure information provided by ...

Creative Commons (CC): This is a Creative Commons license. Attribution (BY): Credit must be given to the creator. In response to extracellular ligands, G protein-coupled receptors (GPCRs) undergo ...