Dysfunctions of the tiny cell processes (primary cilia) of the pancreatic beta cells could be a cause of type 2 diabetes.

Role in Signal Transmission Between Beta Cells and Islet Cells The researchers also examined how cilia interact with neighboring cells to infer their signaling functions. They found that primary cilia ...

The beta cells of the pancreas are responsible for releasing ... neighboring cells in order to draw conclusions about their signaling functions. They found that the primary cilia exchange ...

thus making it easier for pancreatic cancer cells to migrate and invade other tissues. Crucially, Salmena and his team also identified the signaling pathway by which INPP4B drives the movement of ...

In the other four patients the insulin levels of the right hepatic vein increased to a near similar extent after calcium stimulation of each of the three arteries. This was considered compatible with ...

This study provides convincing evidence for functional subpopulations of β-cells responsible for Ca2+ signal initiation and maintenance using novel three-dimensional light sheet microscopy imaging and ...

This review explores the role of lysosomal stress in pancreatic diseases, particularly diabetes mellitus. Lysosomes, crucial ...

However, the importance of SGs in determining cell fate and the precise ... to diverse environmental signals. Here, the signaling pathways that connect lysosomal stress to SG formation are ...