How a tiny RNA molecule in the kidney triggers a deadly autoimmune disease

Researchers at the University Hospital Bonn (UKB) and the University of Bonn have discovered how a small, naturally occurring RNA molecule in the kidney activates a mutated immune receptor, triggering ...
Frontiers

Bexarotene signaling in human B and T lymphocytes induces gut-homing receptor expression

Background: Retinoic acid (RA) receptors (RARs) in human lymphocytes modulate the humoral and intestinal immune response by regulating target genes, including CD38, TGM2, and gut-homing markers. The ...
C&EN

Conformational Heterogeneity Underlying Divergent Signaling in Class A G Protein-Coupled Receptors

You are free to share (copy and redistribute) this article in any medium or format and to adapt (remix, transform, and build upon) the material for any purpose, even commercially within the parameters ...
eLife

Non-equilibrium strategies enabling ligand specificity by signaling receptors

This study presents a valuable finding about how receptor-ligand binding pathways with multi-site phosphorylation can show non-monotonic responses to increasing ligand affinity and to kinase activity.