Leucine-rich repeat–containing protein 15 (LRRC15) is a cell surface protein that has emerged as a significant biomarker in cancer biology. This protein is minimally expressed in normal healthy tissue ...

Dr. Bernd Pichler is a distinguished pioneer in preclinical and translational imaging, renowned for his groundbreaking work ...

RECIST was developed in 2000 by the National Cancer Institute, European Organization for Research and Treatment of Cancer, and National Cancer Institute of Canada, with revision to RECIST 1.1 in 2009 ...

Fibroblast activation protein (FAP) has become an attractive target for diagnosis and therapy, and a series of FAP inhibitor (FAPI)–based radiotracers has been developed and had excellent performance ...

The immune-fibrosis axis plays a critical role in cardiac remodeling after acute myocardial infarction. Imaging approaches to monitor temporal inflammation and fibroblast activation in mice have seen ...

Protein tyrosine kinase-7 (PTK7), a member of receptor tyrosine kinase superfamily initially identified as colon carcinoma kinase-4, is highly expressed in various human malignancies. Its expression ...

The translation of radiolabeled tumor-targeting peptides into clinical routine is often hampered by an enhanced accumulation into the excreting organs. It has recently been reported that the (EH)3 ...

PET imaging has the ability to offer valuable functional information, playing a key role in the diagnosis, staging, and evaluation of cancer; the planning of radiotherapy; and the diagnosis of some ...

Journal of Nuclear Medicine October 2025, jnumed.125.270151; DOI: https://doi.org/10.2967/jnumed.125.270151 ...

Targeted diagnosis and therapy enable precise tumor detection and treatment. Successful examples for precise tumor targeting are diagnostic and therapeutic radioligands. However, patients with tumors ...

Journal of Nuclear Medicine October 2025, jnumed.125.270215; DOI: https://doi.org/10.2967/jnumed.125.270215 ...

The 18F-labeled fibroblast activation protein inhibitor (FAPI) [18F]FAPI-74 has the benefit of a higher synthetic yield and better image resolution than 68Ga-labeled FAPI. We preliminarily evaluated ...