Larger studies looking at the benefits and harms of anti-TNF compared with conventional treatment for children with active Crohn's disease are needed. Among the important outcomes to be included are ...

Due to a lack of robust evidence, we could not determine the benefits and unwanted effects of hospital networks (organised trauma systems) or individual hospitals (designated trauma centres) that are ...

Large studies are needed to see if targeted therapies work in the different types of IIM. As IIM is rare, this would best be done by many centres working together internationally.

We found nine studies involving a total of 689 women with stress urinary incontinence. Nine studies compared vaginal lasers to either sham or lubricant, and one study compared vaginal lasers to ...

- Corticosteroids may decrease transient inflammatory reaction events associated with antibiotic treatment of leptospirosis infection, although the certainty of this evidence is very uncertain.

Palivizumab, when given through the veins or into a muscle (systemically), reduces hospitalisations due to respiratory syncytial virus (RSV) and reduces respiratory problems later on (chest wheezing), ...

Transcranial laser therapy (low-level light therapy applied to the head) does not reduce the number of people who die or have moderate to severe disability at 90 days after ischaemic stroke (where ...

Dysmenorrhoea is a common gynaecological problem consisting of painful cramps accompanying menstruation, which in the absence of any underlying abnormality is known as primary dysmenorrhoea. Research ...

Subclinical hypothyroidism is a condition where some laboratory findings point at a thyroid gland not working properly. Patients with subclinical hypothyroidism may have vague, non-specific symptoms ...

Vitamin C supplementation may help reduce the risk of pregnancy complications such as pre-eclampsia, intrauterine growth restriction and maternal anaemia. There is a need to evaluate the efficacy and ...

Urinary tract infection (UTI), worldwide, is a major source of disease in children and adults. As it may have long-term consequences such as kidney failure and hypertension, it is important to treat ...

Shigella dysentery is a relatively common illness and occasionally causes death, worldwide. Mild symptoms are self-limiting but in more severe cases, antibiotics are recommended for cure and ...