What Happens to the Brain in Alzheimer's Disease?
The beta-amyloid 42 form is thought to be especially toxic. In the Alzheimer’s brain, abnormal levels of this naturally occurring protein clump together to form plaques that disrupt cell function. Research is …
Blood test can predict presence of beta-amyloid in the brain, new …
Feb 17, 2022 · A new blood test that predicts amyloid plaques in the brain shows promise as a cost-effective, noninvasive alternative to brain imaging and spinal tap tests, an NIA-funded study finds.
NIA statement on amyloid beta protein dementia research
Jul 29, 2022 · More than six million Americans are currently living with Alzheimer’s disease, and it is predicted that this number will rise to over 13 million by 2060. In addition, many people have other …
Estimates of amyloid onset may predict Alzheimer’s progression
Feb 2, 2023 · Determining how long beta-amyloid plaques have been building up in a person’s brain may help predict the course of their Alzheimer’s disease.
A gene guiding brain cell growth may regulate Alzheimer’s plaque size ...
Apr 10, 2025 · An NIH-funded study suggests that the gene PLXNB1 affects the size and toxicity of beta-amyloid plaques by regulating how glial cells form netlike structures around these proteins. A …
Illuminating the structure of amyloid plaques - National Institute on …
Feb 6, 2018 · Scientists used a new type of tissue sample staining dye in hopes of better understanding the wide architectural variety of misfolded beta-amyloid plaque deposits in the brains of people with …
Amyloid structure linked to different types of Alzheimer’s disease
Jun 2, 2022 · The structure of filaments that come together to form amyloid plaques differ depending on whether a person has sporadic or inherited Alzheimer’s disease, or a different degenerative brain …
Role of glucose metabolism in Alzheimer’s disease
Sep 13, 2024 · The findings suggest that beta-amyloid and tau boost IDO1 activity in astrocytes. This reduces glucose metabolism and lactate production. The loss of lactate, in turn, deprives neurons of …
Blood test method may predict amyloid deposits in brain, potentially ...
Oct 10, 2019 · A research team supported in part by NIA developed a test method that can quantify beta-amyloid in blood samples.
Blood test for early Alzheimer’s detection - National Institute on Aging
Jan 12, 2023 · From NIH Research Matters One of the first stages of Alzheimer’s disease involves formation of toxic aggregates, called oligomers, of the protein beta-amyloid. These oligomers can …